has function has role immunizes against disease immunizes recipient test in lab animal model lung cancer Mus musculus Homo sapiens recombinant vector vaccine therapeutic vaccine function DNA vaccine role vaccine in clinical trial role recombinant vector vaccine role lung cancer vaccine Recombinant DNA-L523S Vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5156 cancer vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT00062907 Jimmy Guo Jie Zheng NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C49290 A plasmid DNA encoding human L523S, an RNA-binding protein that belongs to the KOC (K homology domain containing protein overexpressed in cancer) family, with potential antineoplastic activity. Vaccination with L523S DNA may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells that express the L523S protein. As an oncofetal protein, L523S is normally expressed in early embryonic tissue, but is overexpressed in certain cancer cell types. PMID:12750279 5156 Gene name: IGF2BP3 10643 Oliver He Virginia He https://github.com/vaccineontology/VO/issues/327 therapeutic cancer vaccine DNA cancer vaccine