has function has role immunizes against disease immunizes recipient test in lab animal model melanoma Mus musculus Homo sapiens conjugate vaccine melanoma vaccine therapeutic vaccine function conjugate vaccine role vaccine in clinical trial role PEP-3-KLH conjugate vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5480 5480 Virginia He NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74070 PMID:14519652 cancer vaccine 1956 A cancer vaccine consisting of PEP-3, a synthetic peptide encompassing a tumor-specific mutated segment of the epidermal growth factor receptor type vIII (EGFRvIII), conjugated to the naturally-occurring immunoadjuvant keyhole limpet hemocyanin (KLH) with potential immunostimulating and antineoplastic activities. Upon administration, PEP-3-KLH conjugate vaccine may induce a cytotoxic immune response against tumor cells that overexpress EGFRvIII; this antitumoral immune response may involve antibody-dependent cellular cytotoxicity (ADCC). Gene name: EGFR Jimmy Guo Jie Zheng Oliver He NCT: https://clinicaltrials.gov/ct2/show/NCT00626015 https://github.com/vaccineontology/VO/issues/117 therapeutic cancer vaccine