has function has role immunizes against disease immunizes recipient test in lab animal model melanoma Mus musculus Homo sapiens melanoma vaccine recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role plasmacytoid dendritic cell vaccine Gene name: CLEC4C NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C103192 8829 PMID:30049538 Jie Zheng 170482 cancer vaccine 3598 Oliver He 54106 A whole cell vaccine derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology that exhibits immunomodulating activity. Plasmacytoid dendritic cells (pDCs) express a characteristic set of surface markers, such as CD123 (interleukin-3 receptor alpha chain), BDCA-2 (blood dendritic cell antigen 2; CD303) and BDCA-4 (CD304), as well as intracellular toll-like receptors 7 and 9. Upon stimulation, the activated pDCs produce substantial amounts of interferon (IFN) alpha, and to a lesser degree IFN-beta, as well as other cytokines and chemokines, such as tumor necrosis factor alpha and interleukins 1, 6 and 8. In addition, these pDCs, directly or indirectly stimulate T-cells, B-cells and natural killer cells. This may potentially lead to increased immunity against tumor cells. https://github.com/vaccineontology/VO/issues/121 Gene name: IL13RA2 5006 NCT: https://clinicaltrials.gov/ct2/show/NCT01690377 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5006 Gene name: TLR9 Gene name: TLR7 Virginia He 51284 Jimmy Guo Gene name: NRP1 therapeutic cancer vaccine