has function has role immunizes against disease immunizes recipient melanoma Homo sapiens melanoma vaccine subunit vaccine therapeutic vaccine function subunit vaccine role vaccine in clinical trial role recombinant human Hsp110-gp100 chaperone complex vaccine Jimmy Guo NCT: https://clinicaltrials.gov/ct2/show/NCT01744171 cancer vaccine Virginia He Gene name: gp100 (PMEL) Jie Zheng Oliver He 5359 6490 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C103830 PMID:12750279 A recombinant chaperone-peptide complex-based vaccine composed of a complex between heat shock protein hsp110 and the human melanoma-associated antigen gp100, with potential antineoplastic activity. Upon vaccination, recombinant hsp110-gp100 chaperone complex activates the immune system to exert a cytotoxic T cell immune response and antigen-specific interferon-gamma production against gp100-overexpressing cancer cells. Gp100, is overexpressed in a variety of cancer cell types. Hsp110, binds to and chaperones full-length proteins during heat shock; as an immunoadjuvant it is able to enhance an immune response against antigen(s) and stimulate T-lymphocyte activation. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5359 therapeutic cancer vaccine