has function has role immunizes against disease immunizes recipient melanoma Homo sapiens melanoma vaccine recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role recombinant Vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine 6490 Gene name: Cd86 5232 cancer vaccine 2315 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48638 PMID:30626434 Jimmy Guo Gene name: MLANA-Dupli Virginia He Gene name: CD80 12524 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5232 Gene name: gp100 (PMEL) 941 Jie Zheng A cancer vaccine consisting of an inactivated recombinant vaccinia virus encoding epitope peptides derived from melanoma-related HLA-A2-restricted tumor-associated antigens (TAAs), including Melan-A(27-35), gp100(280-288) and tyrosinase(1-9), and two co-stimulatory B7 proteins, B7.1 (CD80) and B7.2 (CD86). Upon administration, recombinant vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine may stimulate a cytotoxic T-lymphocyte response against melanoma cells that express TAAs which share epitopes with the epitope peptides expressed by the vaccine viral vector, resulting in tumor cell lysis; vaccine viral vector-expressed co-stimulatory proteins B7.1 and B7.2 may enhance the cytotoxic T-lymphocyte immune response to the TAAs. Oliver He therapeutic cancer vaccine