has function has role vaccinated in route immunizes against disease immunizes recipient test in lab animal model melanoma Mus musculus Homo sapiens intramuscular route melanoma vaccine therapeutic vaccine function DNA vaccine role vaccine in clinical trial role Synchotrope TA2M DNA vaccine https://github.com/vaccineontology/VO/issues/407 Oliver He 7299 NCT: https://clinicaltrials.gov/ct2/show/NCT00023647 Gene name: Tyrosinase VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4002 Jie Zheng NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2650 5218 PMID:12833467 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5218 4002 A recombinant plasmid DNA vaccine encoding epitopes of tyrosinase with potential antineoplastic activity. Synchotrope TA2M vaccine contains a plasmid encoding 2 epitopes, amino acid sequences 207-216 and 1-17 of tyrosinase, a protein frequently expressed by melanoma cells. Vaccination with the TA2M plasmid DNA vaccine may induce the production of anti-tyrosinase antibodies as well as elicit a cytotoxic T-lymphocyte (CTL) response against tyrosinase-expressing tumor cells, resulting in decreased tumor growth. cancer vaccine Virginia He Jimmy Guo therapeutic cancer vaccine DNA cancer vaccine