has function has role immunizes against disease immunizes recipient test in lab animal model melanoma Mus musculus Homo sapiens melanoma vaccine therapeutic vaccine function DNA vaccine role vaccine in clinical trial role Synchrovax SEM plasmid DNA vaccine Gene name: MLANA-Dupli Jie Zheng Gene name: Tyrosinase cancer vaccine 5506 A bivalent DNA vaccine encoding epitopes for both Melan-A (MART-1) and tyrosinase with potential antineoplastic activity. Synchrovax SEM plasmid DNA vaccine contains a plasmid pSEM that encodes 4 epitopes: Melan-A (26-35), Melan-A (31-96), tyrosinase (1-9), and tyrosinase (369-377). Both Melan-A and tyrosinase are tumor antigens associated with melanoma. Vaccination with this plasmid DNA vaccine may induce both humoral and cytotoxic lymphocyte (CTL) responses against cells expressing either or both of these antigens, resulting in decreased tumor growth. Virginia He Jimmy Guo 2315 https://github.com/vaccineontology/VO/issues/408 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28549 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5506 Oliver He NCT: https://clinicaltrials.gov/ct2/show/NCT00033228 7299 therapeutic cancer vaccine DNA cancer vaccine