has function has role immunizes against disease immunizes recipient multiple myeloma Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role myeloma cancer vaccine XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410 A cancer vaccine containing immunogenic, HLA-A2-specific epitopes derived from X-box-binding protein 1-unspliced (XBP1-US), XBP1-spliced (SP), syndecan-1 (CD138), and CS1 (CD2 subset 1, CRACC, SLAMF7, CD319) with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, XBP1-US/XBP1-SP/CD138/CS1 multipeptide vaccine PVX-410 may stimulate the immune system to induce a cytotoxic T-lymphocyte response against the four myeloma-specific antigens. The tumor associated antigens (TAAs) XBP1-US, XBP1-SP, CD138 and CS1, are overexpressed on the surface of multiple myeloma (MM) cells. Gene name: Xbp1 6382 5415 57823 NCT: https://clinicaltrials.gov/ct2/show/NCT01718899 Jimmy Guo PMID:30128502 cancer vaccine Gene name: SLAMF7 Virginia He Oliver He Jie Zheng 22433 Gene name: SDC1 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5415 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C103823 therapeutic cancer vaccine