has function has role immunizes against disease immunizes recipient test in lab animal model ovarian cancer Mus musculus Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role ovarian cancer vaccine PA-1-STK Ovarian Carcinoma Vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT00006216 cancer vaccine Virginia He Oliver He https://github.com/vaccineontology/VO/issues/57 A cell-based cancer vaccine with potential antineoplastic activity. PA-1-STK ovarian carcinoma vaccine is produced by transducing the ovarian cancer cell line, PA-1, with the herpes simplex thymidine kinase (HSV-tk) gene, resulting in a cell line, PA-1-STK, that permanently expresses the HSV tk gene. Upon transfection into malignant cells, this vaccine is capable of sensitizing tumor cells in response to an antiviral drug such as ganciclovir, which is readily phosphorylated by the TK enzyme to its active form. Administration of ganciclovir following PA-1 STK transfection results in enhanced cytotoxicity of the transfected tumor cells. Additionally, adjacent non-transfected cells are also killed by the activated antiviral drug, a phenomenon referred to as the bystander effect that occurs with this type of suicide-gene transfer technique. Jimmy Guo Jie Zheng PMID:7578411 5245 Gene name: PAGR1 79447 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2428 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5245 therapeutic cancer vaccine