has function has role immunizes against disease immunizes recipient test in lab animal model ovarian cancer Mus musculus Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role recombinant viral vector vaccine ovarian cancer vaccine Pexastimogene-devacirepvec Vaccine Gene name: hGM-CSF NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71533 An oncolytic thymidine kinase (TK)-deleted vaccinia poxvirus expressing human GM-CSF (hGM-CSF) with antineoplastic activity. Upon intratumoral or intravenous administration, pexastimogene devacirepvec selectively infects and lyses tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the TK gene increases the tumor selectivity of vaccinia by limiting viral replication to cells expressing high levels of TK, such as certain cancer cells. hGM-CSF expression by this agent helps recruit antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages, to virally infected tumor cells, thereby initiating an antitumoral immune response. Oliver He https://github.com/vaccineontology/VO/issues/119 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5078 cancer vaccine 1437 Jimmy Guo NCT: https://clinicaltrials.gov/ct2/show/NCT02562755 5078 Jie Zheng PMID:31413923 Virginia He therapeutic cancer vaccine