has function has role immunizes against disease immunizes recipient pancreatic cancer Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role pancreatic cancer vaccine VEGFR1-1084 Peptide Vaccine PMID:26190488 A peptide vaccine containing an HLA-A*2402-restricted epitope of vascular endothelial growth factor receptor 1 (VEGFR1 or Flt-1) with potential immunostimulating, antiangiogenic, and antineoplastic activities. Upon vaccination, VEGFR1-1084 peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against VEGFR1-expressing endothelial cells of the tumor microvasculature, which may inhibit tumor angiogenesis and tumor cell proliferation. VEGFR1, a receptor tyrosine kinase, may be overexpressed on endothelial cells of the tumor microvasculature and is associated with tumor cell proliferation, invasion and tumor angiogenesis. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenicity. 2321 Virginia He NCT: https://clinicaltrials.gov/ct2/show/NCT00655785 Oliver He Jimmy Guo Gene name: FLT1 Jie Zheng cancer vaccine 5214 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5214 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C77895 therapeutic cancer vaccine