has function has role immunizes against disease immunizes recipient prostate cancer Homo sapiens RNA vaccine recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role RNA vaccine role prostate cancer vaccine Primary Prostate Cancer Tissue/hTERT/Survivin mRNA-loaded Autologous Dendritic Cell Vaccine Gene name: TERT Jie Zheng NCT: https://clinicaltrials.gov/ct2/show/NCT00345293 Jimmy Guo 7015 cancer vaccine An autologous dendritic cell (DCs) vaccine targeting prostate cancer with immunostimulating activity. The autologous DC vaccine is prepared via transfecting DCs with mRNAs extracted from primary prostate cancer tissue, and mRNAs of human telomerase reverse transcriptase (hTERT) and survivin. Upon administration, this DC vaccine may elicit a potent cytotoxic T-cell (CTL) response against prostate cancer cells, resulting in tumor cell death. Both hTERT and survivin are essential in neoplastic growth, and are considered to be universal tumor antigens. Virginia He VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5205 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C95771 5205 PMID:30505813 Oliver He therapeutic cancer vaccine