has function has role immunizes against disease immunizes recipient test in lab animal model prostate cancer Mus musculus Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role prostate cancer vaccine PSMA/TARP Peptide Vaccine 354 NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C78819 cancer vaccine Gene name: KLK3 Jimmy Guo Oliver He VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5052 PMID:34494382 Virginia He Jie Zheng NCT: https://clinicaltrials.gov/ct2/show/NCT00694551 https://github.com/vaccineontology/VO/issues/184 5052 A peptide-based cancer vaccine containing epitopes of T cell receptor gamma-chain alternate reading frame protein (TARP) and prostate-specific membrane antigen (PSMA) in combination with a Poly IC-LC immunoadjuvant, with potential antineoplastic activity. Upon administration, PSMA/TARP peptide vaccine may stimulate a host cytotoxic T-cell (CTL) response against TARP- and PSMA-expressing tumor cells, resulting in tumor cell cytotoxicity. The nuclear protein TARP and PSMA are commonly expressed in prostate cancer cells. therapeutic cancer vaccine