has function has role immunizes against disease immunizes recipient prostate cancer lung cancer breast cancer colon cancer ovarian cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role prostate cancer vaccine breast cancer vaccine lung cancer vaccine colon cancer vaccine ovarian cancer vaccine Ad-sig-hMUC-1/ecdCD40L vaccine 5179 Jie Zheng Gene name: MUC1 Eliyas Asfaw 959 https://ascopubs.org/doi/10.1200/JCO.2018.36.15_suppl.3098 4582 cancer vaccine Gene name: CD40LG Oliver He A cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor-associated antigen (TAA) human MUC-1 (hMUC-1) linked to the extracellular domain (ecd) of the co-stimulatory molecule CD40 ligand (CD40L) and an adenovirus signal sequence that encodes a secretory signal peptide (Ad-sig) with potential immunostimulating and antineoplastic activities. Due to the presence of the secretory signal peptide expressed by Ad-sig in the vaccine construct, transfected cells may secrete a fusion protein composed of hMUC-1 and the CD40L ecd. The CD40L moiety part of the fusion protein binds to CD40 receptors on dendritic cells (DCs). Subsequently, DCs may be activated and migrate, T-cells may expand, and a cytotoxic T lymphocyte (CTL) response against tumor cells that overexpress hMUC-1 may follow. MUC-1 is a hypoglycosylated TAA overexpressed by epithelial cancer cells. https://github.com/vaccineontology/VO/issues/88 Ibrahim Seleznev VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5179 therapeutic cancer vaccine