has function has role immunizes against disease immunizes recipient colon cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role colon cancer vaccine Adenoviral Vector Ad5-CEA(6D) Vaccine PMID:25956394 Eliyas Asfaw A replication-defective, E1- and E2b-deleted oncolytic adenoviral serotype 5 (Ad5) encoding an epitope of human carcinoembryonic antigen (CEA) with potential antineoplastic activity. Adenoviral vector Ad5-CEA(6D) vaccine expresses a highly immunogenic analogue of CEA [CAP1-(6D)]. Upon administration, this vaccine may induce both humoral and cellular immune responses against tumor cells expressing the CEA antigen, thereby resulting in the immune-mediated inhibition of tumor cell proliferation and tumor cell death. CEA, a tumor-associated antigen, is overexpressed in various tumor cell types. Deletion of early genes E1 and E2b in Ad5 potentially circumvent pre-existing anti-adenovirus immunity and is capable of inducing strong immune responses. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5137 Ibrahim Seleznev 5137 1048 https://github.com/vaccineontology/VO/issues/94 cancer vaccine Oliver He Gene name: CEACAM5 Jie Zheng therapeutic cancer vaccine