has function has role immunizes against disease immunizes recipient prostate cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role prostate cancer vaccine AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine cancer vaccine Ibrahim Seleznev A cell-based vaccine comprised of prostate cancer cells transduced with an adenoviral vector encoding human RTVP-1 (AdRTVP-1), with potential antineoplastic and immunostimulating activities. RTVP-1, also referred to as glioma pathogenesis-related protein 1 (GLIP1), is down-regulated in prostate tumors. Regulated by tumor suppressor p53, the expression of RTVP-1 functions as a tumor suppressor, and is abundant in normal human prostate epithelial cells as well as in differentiated macrophages. Administration of this vaccine leads to an induction of apoptosis through the expression of RTVP-1 and results in a reduction in cellular proliferation in prostate cancer cells. In addition, this cancer-cell based vaccine may induce a cytotoxic T lymphocyte (CTL) response against prostate specific tumor associated antigens, resulting in an immune-mediated prostate cancer cell death. Furthermore, RTVP-1 stimulates CTL and natural killer (NK) cell activities. 11010 https://github.com/vaccineontology/VO/issues/106 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5203 5203 Gene name: GLIPR1 Jie Zheng Oliver He Eliyas Asfaw therapeutic cancer vaccine