has function has role immunizes against disease immunizes recipient cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role allogeneic dendritic cell vaccine COMBIG-DC 5446 Oliver He Jie Zheng Gene name: TNF NCT: https://clinicaltrials.gov/ct2/show/NCT01974661 Eliyas Asfaw Ibrahim Seleznev cancer vaccine NCT: https://clinicaltrials.gov/ct2/show/NCT01525017 A cancer vaccine consisting of allogeneic, immortalized dendritic cells (DCs) loaded with tumor specific antigens and activated, with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration of the allogeneic dendritic cell vaccine COMBIG-DC, these activated DCs attract natural killer (NK) cells, induce an anti-inflammatory response leading to the induction of NK-cell-mediated tumor cell death. Upon release of tumor associated antigens (TAAs) from the lysed tumor cells, these antigens are taken up by antigen presenting cells which activate the immune system to elicit a potent cytotoxic T-cell (CTL) response against the TAAs, resulting in the death of TAAs-expressing tumor cells. 3458 https://github.com/vaccineontology/VO/issues/149 Gene name: IFNG 7124 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5446 therapeutic cancer vaccine