has function has role immunizes against disease immunizes recipient pancreatic cancer Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role pancreatic cancer vaccine Allogeneic GM-CSF-secreting Tumor Vaccine PANC 10.05 pcDNA-1/GM-Neo VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5075 Jie Zheng Oliver He NCT: https://clinicaltrials.gov/ct2/show/NCT01088789 Ibrahim Seleznev Eliyas Asfaw An allogeneic cancer vaccine composed of lethally irradiated, whole pancreatic cancer cells transfected with a plasmid carrying the gene for cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Allogeneic GM-CSF-secreting tumor vaccine PANC 10.05 pcDNA-1/GM-Neo secretes GM-CSF thereby activating dendritic cells, promoting antigen presentation to B- and T-cells, and promoting a cytotoxic T-lymphocyte (CTL) response. This may eventually kill tumor cells. The pancreatic tumor cells are derived from the PANC 10.05 tumor cell line. https://github.com/vaccineontology/VO/issues/154 cancer vaccine 5075 therapeutic cancer vaccine DNA cancer vaccine