has function has role immunizes against disease immunizes recipient kidney cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role renal cancer vaccine Allogeneic Renal Cell Carcinoma Vaccine MGN1601 941 https://github.com/vaccineontology/VO/issues/161 cancer vaccine Gene name: CD40LG Oliver He Jie Zheng 959 A whole cell vaccine comprised of irradiated allogeneic renal cell carcinoma (RCC) with potential immunostimulating and antineoplastic activities. Allogeneic renal cell carcinoma vaccine MGN1601 contains two active ingredients: 1) genetically modified allogeneic RCC cells that are transiently transfected with four different MIDGE (Minimalistic Immunogenically Defined Gene Expression) vectors encoding IL-7, GM-CSF, CD80 and CD154 and 2) the synthetic DNA-based immunomodulator dSLIM-30L1, a TLR9 agonist.. Vaccination results in expression of IL-7, GM-CSF, CD80 and CD154, which all contribute to the activation or enhancement of immune responses. Furthermore, administration of this RCC vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity. Eliyas Asfaw VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5358 Ibrahim Seleznev 5358 https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)36654-0 Gene name: CD80 therapeutic cancer vaccine