has function has role immunizes against disease immunizes recipient breast cancer Homo sapiens subunit vaccine therapeutic vaccine function subunit vaccine role vaccine in clinical trial role breast cancer vaccine antigen-targeted Personalized Breast Cancer Vaccine Jie Zheng Eliyas Asfaw 5138 Oliver He 6490 An individualized, therapeutic cancer vaccine (IVAC) composed of liposomes containing RNA encoding two or three tumor associated antigens (TAAs) that are specifically expressed in the patient's individual cancer selected from a warehouse (""off the shelf"") and p53 RNA, with potential immunostimulatory and antineoplastic activities. Upon administration, the antigen-targeted personalized breast cancer vaccines are translated by antigen presenting cells (APCs) and the expressed protein is presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL) and memory T-cell immune responses against the TAAs. The RNAs in the vaccine are specifically selected for an individual patient after RNA profiling of the patient's tumor. Ibrahim Seleznev Gene name: gp100 (PMEL) cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5138 https://github.com/vaccineontology/VO/issues/238 therapeutic cancer vaccine