has function has role immunizes against disease immunizes recipient melanoma Homo sapiens melanoma vaccine recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role autologous anti-gp100:154-162 T-cell receptor gene-engineered peripheral blood lymphocytes vaccine 5507 NCT: https://clinicaltrials.gov/ct2/show/NCT00509496 Gene name: gp100 (PMEL) Oliver He 6490 Jie Zheng cancer vaccine https://github.com/vaccineontology/VO/issues/244 Human autologous peripheral blood lymphocytes (PBLs) transduced with a glycoprotein 100 (gp100) epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector encoding the TCR specific for amino acid residues 154-162 of gp100 (KTWGQYWQV). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient and bind to melanoma cells expressing the gp100 protein, which may result in specific cytotoxic T-lymphocyte (CTL) killing of gp100-expressing melanoma cells. gp100 is a melanocyte lineage-specific antigen overexpressed in melanomas. Eliyas Asfaw VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5507 Ibrahim Seleznev therapeutic cancer vaccine