has function has role immunizes against disease immunizes recipient leukemia Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role leukemia cancer vaccine Autologous CD40L-expressing B-CLL Vaccine https://github.com/vaccineontology/VO/issues/247 Eliyas Asfaw 5174 Oliver He Jie Zheng Ibrahim Seleznev 959 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5174 Gene name: CD40LG cancer vaccine A cancer vaccine consisting of autologous, B-chronic lymphocytic leukemia (B-CLL) cells harvested from a patient and transduced with an adenoviral vector encoding the gene for the human CD40 ligand (CD40L; TRAP; CD154), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous CD40L-expressing B-CLL vaccine expresses the co-stimulatory molecule CD40L, which binds to its cognate receptor, CD40, on antigen presenting cells (APC). This induces apoptosis, stimulates maturation and proliferation of APCs, and facilitates a cytotoxic T-lymphocyte (CTL) response against tumor cells. CD40L is a type II membrane protein that binds to CD40, which is a cell surface receptor that belongs to the tumor necrosis factor (TNF) receptor superfamily. therapeutic cancer vaccine