has function has role immunizes against disease immunizes recipient melanoma Homo sapiens melanoma vaccine recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role autologous melanoma Lysate/NY-ESO-1-pulsed autologous dendritic cell vaccine https://github.com/vaccineontology/VO/issues/276 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5158 Eliyas Asfaw Ibrahim Seleznev Gene name: NY-ESO-1 5158 A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with both a lysate from autologous melanoma cells containing tumor associated antigens (TAAs) and a synthetic peptide derived from the tumor associated antigen human cancer-testis antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities. Upon administration, autologous melanoma lysate/NY-ESO-1-pulsed autologous DC vaccine may stimulate the immune system to mount anti-tumoral cytotoxic T lymphocyte (CTL) and antibody-mediated immune responses against melanoma cells, which may result in melanoma cell lysis. NY-ESO-1 is expressed in normal testes and on the surfaces of various tumor cells, and plays a key role in tumor cell proliferation and survival. 1485 Jie Zheng Oliver He cancer vaccine therapeutic cancer vaccine