has function has role immunizes against disease immunizes recipient lung cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function DNA vaccine role vaccine in clinical trial role recombinant vector vaccine role lung cancer vaccine Autologous NSCLC DNA-Transfected Semi-Allogeneic Fibroblasts MRC-5 Vaccine Jie Zheng 5377 Oliver He Eliyas Asfaw Ibrahim Seleznev cancer vaccine A vaccine consisting of irradiated human fetal lung fibroblasts (Medical Research Council 5 or MRC-5) transfected with autologous non-small cell lung cancer (NSCLC)-derived DNA with potential immunostimulatory and antineoplastic activities. Upon administration, autologous NSCLC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine expresses NSCLC tumor-associated antigens (TAAs) in addition to MHC class I-determinants and the co-stimulatory molecule B7.1, which may induce a cytotoxic T-lymphocyte (CTL) response against NSCLC cells. The MRC-5 cell line is a human diploid lung fibroblast cell line extablished in 1966. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5377 https://github.com/vaccineontology/VO/issues/277 therapeutic cancer vaccine DNA cancer vaccine