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<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/VO?iri=http://purl.obolibrary.org/obo/VO_0007312"?>
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     xml:base="http://www.w3.org/2002/07/owl"
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     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/OGG_0000000006"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/VO_0001818"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000233"/>
    


    <!-- 
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    <!-- 
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    // Object Properties
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    <!-- http://purl.obolibrary.org/obo/RO_0000085 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000085">
        <rdfs:label xml:lang="en">has function</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/VO_0001011 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/VO_0001011">
        <rdfs:label>immunizes against disease</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/VO_0001243 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/VO_0001243">
        <rdfs:label>immunizes recipient</rdfs:label>
    </ObjectProperty>
    


    <!-- 
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    <!-- http://purl.obolibrary.org/obo/DOID_1319 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_1319">
        <rdfs:label xml:lang="en">brain cancer</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:label>Homo sapiens</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0000562 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000562">
        <rdfs:label>therapeutic vaccine function</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0000631 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000631">
        <rdfs:label>vaccine in clinical trial role</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0005428 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0005428">
        <rdfs:label>brain cancer vaccine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0007312 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0007312">
        <rdfs:label>Autologous Pluripotent ALDHbr Stem Cells ALD-451 Vaccine</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0005428"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0007657"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0001243"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
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        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0001011"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DOID_1319"/>
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        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0000562"/>
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        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0000631"/>
            </Restriction>
        </rdfs:subClassOf>
        <ns3:OGG_0000000006>216</ns3:OGG_0000000006>
        <ns3:IAO_0000115>A specific population of autologous, pluripotent bone marrow derived cells that express high levels of the cytosolic enzyme aldehyde dehydrogenase (ALDH) with potential protective and neuro-cognition improving activity. Expression of high levels of ALDH is an indicator of the biological activity in heterogenous early stage stem cells. Upon intravenous administration, these ALDH bright cells may protect normal cells and may repair damaged cells. These cells may also protect brain cells from damage and may improve neurocognition.</ns3:IAO_0000115>
        <ns3:OGG_0000000006>217</ns3:OGG_0000000006>
        <ns3:IAO_0000119>VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5220</ns3:IAO_0000119>
        <ns3:IAO_0000119>https://discovery.lifemapsc.com/regenerative-medicine/cell-therapy-applications/brain-ald451-bone-marrow-derived-cells-for-malignant-glioma</ns3:IAO_0000119>
        <rdfs:comment>Gene name: ALDH1A1</rdfs:comment>
        <oboInOwl:inSubset>cancer vaccine</oboInOwl:inSubset>
        <ns3:VO_0001818>5220</ns3:VO_0001818>
        <ns3:IAO_0000117>Eliyas Asfaw</ns3:IAO_0000117>
        <ns3:IAO_0000117>Oliver He</ns3:IAO_0000117>
        <ns3:IAO_0000117>Jie Zheng</ns3:IAO_0000117>
        <rdfs:comment>Gene name: ALDH2</rdfs:comment>
        <ns3:IAO_0000233>https://github.com/vaccineontology/VO/issues/281</ns3:IAO_0000233>
        <ns3:IAO_0000117>Ibrahim Seleznev</ns3:IAO_0000117>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0007657 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0007657">
        <rdfs:label>therapeutic cancer vaccine</rdfs:label>
    </Class>
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