has function has role immunizes against disease immunizes recipient leukemia Homo sapiens therapeutic vaccine function vaccine in clinical trial role leukemia cancer vaccine Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine Eliyas Asfaw VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5108 Ibrahim Seleznev 3558 5108 An autologous chronic lymphocytic leukemia cancer vaccine consisting of patient-specific membrane proteins directly extracted from patient autologous tumor cells and incorporated into liposomes along with Interleukin 2 (IL-2) to produce membrane-patched proteoliposomes, with potential immunostimulating and antineoplastic activities. After subcutaneous injection of the autologous tumor cell proteoliposomes chronic lymphocytic leukemia vaccine, liposomes deliver the encapsulated tumor antigens into the cytosol of antigen presenting cells (APCs). Subsequently, the APCs process the antigens and present antigen-derived peptides to the immune system. This may enhance recognition of tumors by the immune system, and activate both cytotoxic CD8+ T cells and CD4+ helper T cells against tumor cells. IL-2 is incorporated into the vaccine to leverage its ability to expand activated T cells. Jie Zheng Oliver He cancer vaccine Gene name: IL2 https://github.com/vaccineontology/VO/issues/287 therapeutic cancer vaccine