has function has role immunizes against disease immunizes recipient breast cancer Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role breast cancer vaccine CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine Gene name: YBX1 A plasmid DNA vaccine containing the mammalian expression vector pUMVC3 (pNGVL3) encoding epitopes of CD105 (Endoglin), Y-box binding protein 1 (Yb-1), SRY-box 2 (SOX2), cadherin 3 (CDH3), and murine double minute 2 (MDM2) proteins, with potential immunomodulating and antineoplastic activities. Upon intradermal administration of pUMVC3-CD105/Yb-1/SOX2/CDH3/MDM2-epitopes plasmid DNA vaccine, the plasmid transfects cells and the peptides are expressed. This generates a specific memory Th1 (T-helper) cell immune response, stimulates secretion of cytokines by the T cells and leads to a cytotoxic T-lymphocyte (CTL) response against CD105/Yb-1/SOX2/CDH3/MDM2-expressing tumor cells. CD105/Yb-1/SOX2/CDH3/MDM2 proteins are highly immunogenic tumor associated antigens that are overexpressed in breast cancer. Additionally, these antigens are associated with breast cancer stem cells and with epithelial to mesenchymal transformation (EMT). Gene name: MDM2 2022 https://github.com/vaccineontology/VO/issues/379 5193 Gene name: ENG cancer vaccine 1001 4193 Gene name: CDH3 Gene name: SOX2 6657 Eliyas Asfaw 4904 Ibrahim Seleznev Oliver He Jie Zheng VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5193 therapeutic cancer vaccine DNA cancer vaccine