has function has role immunizes against disease immunizes recipient colon cancer Homo sapiens toxoid vaccine therapeutic vaccine function DNA vaccine role vaccine in clinical trial role toxoid vaccine role colon cancer vaccine CEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine Eliyas Asfaw A plasmid vaccine encoding wild type human carcinoembryonic antigen (CEA) fused to a tetanus toxoid T helper epitope, with potential antineoplastic activity. Upon vaccination and subsequent intradermal electroporation, CEA/tetanus toxoid T helper epitope fusion protein-expressing DNA plasmid vaccine may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in a variety of cancer cell types. The tetanus toxoid helper peptide epitope, obtained from the bacterial Clostridium tetani toxoid, binds to class II MHC molecules and increases the helper T-cell response thereby inducing an increased and long-term immune response. https://github.com/vaccineontology/VO/issues/383 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5367 cancer vaccine Oliver He Ibrahim Seleznev Jie Zheng Gene name: CEACAM5 (CEA) 1048 5367 therapeutic cancer vaccine DNA cancer vaccine