has function has role immunizes against disease immunizes recipient cervical cancer Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role cervical cancer vaccine DNA Vaccine VB10.16 PMID:36129459 Gene name: E6 https://github.com/vaccineontology/VO/issues/403 5207 Gene name: E7 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5207 1489079 cancer vaccine 1489078 Oliver He Jie Zheng Ibrahim Seleznev A therapeutic DNA vaccine composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), the second is a dimerization entity and the third part encodes a protein that specifically binds to antigen presenting cells (APCs), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration, the DNA vaccine VB10.16 expresses HPV16 E6/7 and a protein that targets receptors on APCs. Upon binding to APCs and subsequent internalization, the APCs mature and the HPV16 E6/7 antigenic protein is presented by the APCs. This attracts and stimulates B-lymphocytes, CD4-positive T-lymphocytes and elicits a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV16-associated E6 and E7 oncoproteins, which result in tumor cell lysis. HPV16 E6/7, a viral antigen, plays a key role in the development of certain types of cancer. Eliyas Asfaw therapeutic cancer vaccine DNA cancer vaccine