has function has role immunizes against disease immunizes recipient brain cancer Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role brain cancer vaccine IDH1R132H-Specific Peptide Vaccine PEPIDH1M Oliver He Jie Zheng Yuanyi (Penny) Pan 5461 https://github.com/vaccineontology/VO/issues/459 Justin Song cancer vaccine 3417 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5461 Gene name: IDH1 A peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1 (IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic activity. Intradermal vaccination with the IDH1R132H-specific peptide vaccine PEPIDH1M may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the IDH1R132H protein. The IDH1 point mutation of amino acid residue 132 is highly expressed in gliomas and is associated with increased production of the oncometabolite R-2-hydroxyglutarate therapeutic cancer vaccine