has function has role immunizes against disease immunizes recipient breast cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role breast cancer vaccine HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine Yuanyi (Penny) Pan 2064 5237 A dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted HER-2-derived peptides, with potential immunomodulatory and antineoplastic activities. Autologous DCs were treated with GM-CSF, interleukin-4, interferon-gamma and bacterial lipopolysaccharide (LPS), a toll-like receptor type 4 agonist, to produce highly polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). Upon administration, HER2-pulsed autologous DC vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5237 https://github.com/vaccineontology/VO/issues/306 Justin Song cancer vaccine Oliver He Gene name: ERBB2 Jie Zheng therapeutic cancer vaccine