has function has role immunizes against disease immunizes recipient cancer Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role mutant p53 peptide pulsed dendritic cell vaccine https://github.com/vaccineontology/VO/issues/559 5364 cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5364 Justin Song Oliver He Jie Zheng Yuanyi (Penny) Pan A cancer vaccine consisting of autologous dendritic cells which have been pulsed with a mutant p53 peptide. Vaccination with mutant p53 peptide pulsed dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing mutant p53, resulting in tumor cell lysis. Many tumor cells overexpress mutant p53 proteins, resulting in the loss of apoptosis regulation and abnormal cell proliferation. therapeutic cancer vaccine