has function has role immunizes against disease immunizes recipient stomach cancer lung cancer breast cancer esophageal cancer colorectal cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role colorectal cancer vaccine breast cancer vaccine lung cancer vaccine gastric cancer vaccine esophageal cancer vaccine Globo H-DT vaccine OBI-833 Jie Zheng cancer vaccine 5055 Justin Song A carbohydrate-based vaccine comprised of the Globo H hexasaccharide 1 (Globo H) antigen conjugated to DT-CRM197, a non-toxic, mutated form of diphtheria toxin (DT), with potential immunostimulating and antineoplastic activities. Upon administration of Globo H-DT vaccine OBI-833, the carbohydrate antigen Globo H may stimulate a cytotoxic T-lymphocyte (CTL) response against Globo H-expressing tumor cells, thereby decreasing tumor cell proliferation. The hexasaccharide Globo H is a tumor-associated antigen (TAA) commonly found on a variety of tumor cells. DT-CRM197, also called diphtheria toxin cross-reacting material 197, is used to increase the immunogenicity of the Globo H carbohydrate antigen. https://github.com/vaccineontology/VO/issues/172 Yuanyi (Penny) Pan Gene name: tox1 Oliver He 11716682 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5055 therapeutic cancer vaccine