has function has role immunizes against disease immunizes recipient hepatocellular carcinoma Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role hepatocellular carcinoma vaccine HCV DNA Vaccine INO-8000 Gene name: KRAS https://github.com/vaccineontology/VO/issues/304 5002 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5002 cancer vaccine A multi-antigen DNA vaccine consisting of plasmids encoding the hepatitis C virus (HCV) nonstructural proteins 3 (NS3), 4A (NS4A), 4B (NS4B) and 5A (NS5A), with potential immunomodulating and cancer preventive activities. Administered via intramuscular injection followed by electroporation, cells transfected with the HCV DNA vaccine INO-8000 express the encoded HCV proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against HCV-infected liver cells expressing the NS3, NS4A, NS4B or NS5A proteins. This results in the eradication of HCV-infected cells. HCV, a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, is associated with the development of hepatocellular carcinoma (HCC) Oliver He Justin Song Jie Zheng Yuanyi (Penny) Pan 3845 therapeutic cancer vaccine DNA cancer vaccine