has function has role immunizes against disease immunizes recipient immunizes against pathogen Human papillomavirus Homo sapiens preventive vaccine function recombinant vector vaccine DNA vaccine role vaccine in clinical trial role recombinant vector vaccine role human papillomavirus vaccine human papillomavirus DNA plasmids therapeutic vaccine VGX-3100 Gene name: E6 1489079 HPV DNA plasmids therapeutic vaccine VGX-3100 1489078 https://github.com/vaccineontology/VO/issues/435 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5226 cancer vaccine Justin Song A DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating and antineoplastic activities. Administered via intramuscular electroporation, HPV DNA plasmids therapeutic vaccine VGX-3100 expresses E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 proteins, resulting in tumor cell lysis. HPV type 16 and HPV type 18 are the most common HPV types involved in cervical carcinogenesis. 5226 Oliver He Jie Zheng Yuanyi (Penny) Pan Gene name: E7 HPV associated cancer preventive cancer vaccine DNA cancer vaccine