has function has role immunizes against disease immunizes recipient immunizes against pathogen Human papillomavirus Homo sapiens preventive vaccine function peptide vaccine vaccine in clinical trial role human papillomavirus vaccine peptide vaccine role human papillomavirus 16 E7 peptide/padre 965.10 vaccine cancer vaccine Gene name: E7 Justin Song A synthetic agent derived from human papillomavirus (HPV) E7 nuclear protein which is used to produce vaccines against HPV infection and HPV-related neoplasms. HPV E7 oncogenic protein binds the retinoblastoma tumor suppressor protein, pRB, as well as a number of other cellular proteins, and serves as a transcriptional activator. This protein is important in the induction and maintenance of cellular transformation and is co-expressed in the majority of HPV-containing carcinomas. PADRE(R) is a proprietary family of molecules that enhances the immune systems response against an administered immunogen such as the HPV E7 nuclear protein. https://github.com/vaccineontology/VO/issues/451 5162 Jie Zheng Oliver He VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5162 1489079 Yuanyi (Penny) Pan HPV associated cancer preventive cancer vaccine