has function has role immunizes against disease immunizes recipient immunizes against pathogen Human papillomavirus Homo sapiens preventive vaccine function DNA vaccine role vaccine in clinical trial role human papillomavirus vaccine human papillomavirus E6/E7 DNA vaccine GX-188E 5083 Gene name: E7 cancer vaccine Gene name: E6 Justin Song VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5083 Oliver He A therapeutic DNA vaccine encoding the E6/E7 fusion protein of human papillomavirus (HPV) subtypes 16 and 18, plus the immune-enhancer, Fms-like tyrosine kinase-3 ligand (FLT3L), with potential immunostimulating and antineoplastic activities. DNA vaccine GX-188E is administered using a proprietary delivery system that electroporates the vaccine into cervical cells. Expression of the E6/E7 fusion product may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 oncoproteins, resulting in tumor cell lysis. FLT3L is a ligand for the FLT3 tyrosine kinase receptor, which upon activation stimulates the proliferation of hematopoietic progenitor cells. HPV type 16 and 18 are the most common HPV types involved in cervical carcinogenesis Jie Zheng 1489079 https://github.com/vaccineontology/VO/issues/436 1489078 Yuanyi (Penny) Pan HPV associated cancer preventive cancer vaccine DNA cancer vaccine