has function has role immunizes against disease immunizes recipient lung cancer melanoma Homo sapiens melanoma vaccine therapeutic vaccine function vaccine in clinical trial role lung cancer vaccine IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5173 cancer vaccine Yuanyi (Penny) Pan Jie Zheng A cancer vaccine consisting of allogeneic neuroblastoma tumor cells have been genetically modified to secrete the human cytokine interleukin-2 (IL-2) and the human chemokine lymphotactin (Lptn) with potential immunostimulating and antineoplastic activities. Upon administration, IL-2 and Lptn are secreted by the IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccine, potentially enhancing the cytotoxic T lymphocyte (CTL) response elicited by vaccine neuroblastoma tumor-associated antigens (TAAs) against host neuroblastoma tumor cells. Produced by activated progenitor T cells, Lptn belongs to the C chemokine subfamily and is a potent chemotactic factor for lymphocytes; IL-2 stimulates natural killer (NK) cells and may enhance a vaccine-elicited CTL immune response against tumor cells. Oliver He Gene name: XCL1 https://github.com/vaccineontology/VO/issues/462 6375 Justin Song 5173 therapeutic cancer vaccine