has function has role immunizes against disease immunizes recipient kidney cancer Homo sapiens vaccine in research role therapeutic vaccine function renal cancer vaccine CAR G36-PDL1 vaccine A cancer vaccine made with chimeric antigen receptor (CAR) T cells that can be used to treat solid tumors. These CAR-T cells are engineered to target carbonic anhydrase IX (CAIX) to secrete anti-PD-L1 monoclonal antibody (mAb), termed immune-restoring (IR) CAR G36-PDL1. The T cells can be used to treat clear cell renal cell carcinoma (ccRCC) with reconstituted human leukocyte antigen (HLA) partially matched human leukocytes derived from fetal CD34+ hematopoietic stem cells (HSCs) and bearing human ccRCC skrc-59 cells under the kidney capsule. The cells can restore active antitumor immunity by promoting tumor-killing cytotoxicity, reducing immunosuppressive cell components such as M2 macrophages and exhausted CD8+ T cells, and enhancing T follicular helper (Tfh)-B cell crosstalk. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6380 3105 Hayleigh Kahn Gene name: HLA PMID:38327771 6380 Jie Zheng cancer vaccine therapeutic cancer vaccine