has function has role immunizes against disease immunizes recipient leukemia Homo sapiens therapeutic vaccine function vaccine in clinical trial role leukemia cancer vaccine DC/AML fusion vaccine Jie Zheng NCI: https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148214 A cancer vaccine consisting of autologous dendritic cells (DCs) fused with autologous acute myeloid leukemia (AML) cells, with potential immunostimulatory and antineoplastic activities. It is generated in vitro by mixing DCs and irradiated AML cells harvested from individual patients, in the presence of polyethylene glycol (PEG), to produce hybrid DC-leukemia fusion cells. The vaccine may elicit a cytotoxic T-lymphocyte (CTL)-mediated antitumor immune response against a broad array of AML-associated antigens, which may lead to AML cell lysis. When dendritic cells and tumor cells are brought together, the dendritic cells can stimulate immune responses against the tumor and, in some cases, cause the tumor to shrink. GM-CSF is a drug that stimulates white blood cells and is given with the DC AML Vaccine in an effort to enhance the effect of the vaccine. 6374 NCT: https://clinicaltrials.gov/study/NCT01096602 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6374 NCT: https://clinicaltrials.gov/study/NCT03059485 cancer vaccine Hayleigh Kahn therapeutic cancer vaccine whole cell cancer vaccine