has function has role immunizes against disease immunizes recipient brain cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role brain cancer vaccine dendritic vaccine, allogeneic hematopoietic stem cells, cytotoxic lymphocytes A cancer vaccine made of tumor cells and tumor stem cells that are isolated from a sample from a patient with glioblastoma multiforme. Dendritic cells are isolated from peripheral blood mononuclear cells and cultured. The tumor sample provides tumor specific antigens to prepare the dendritic vaccine. Cytotoxic lymphocytes are obtained from peripheral blood after dendritic vaccine administrations. Hematopoietic stem cells are harvested from closely related donor after granulocyte-colony-stimulating factor (G-CSF) administration. Allogeneic haploidentical hematopoietic stem cells are administered intrathecally, dendritic cells are administered subcutaneously, and cytotoxic lymphocytes are adminstered intrathecally. The combination of these treatments may control tumor cell quantity and target regulation of effector functions of tumor stem cells. Hayleigh Kahn cancer vaccine NCT: https://clinicaltrials.gov/study/NCT01759810 6285 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6285 Jie Zheng therapeutic cancer vaccine whole cell cancer vaccine