has function has role vaccinated in route immunizes against disease immunizes recipient brain cancer Homo sapiens intramuscular route therapeutic vaccine function vaccine in clinical trial role brain cancer vaccine dendritic vaccine, autologous hematopoietic stem cells, cytotoxic lymphocytes 6286 Jie Zheng NCT: https://clinicaltrials.gov/study/NCT01759810 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6286 A cancer vaccine from tumor cells and tumor stem cells that are isolated from a sample from a patient with glioblastoma multiforme. Dendritic cells are isolated from peripheral blood mononuclear cells and cultured. The tumor sample provides tumor specific antigens to prepare the dendritic vaccine. Cytotoxic lymphocytes are obtained from peripheral blood after dendritic vaccine administrations. Hematopoietic stem cells are harvested from closely related donor after granulocyte-colony-stimulating factor (G-CSF) administration. Autologous haploidentical hematopoietic stem cells are administered intrathecally, dendritic cells are administered subcutaneously, and cytotoxic lymphocytes are adminstered intrathecally. The combination of these treatments may control tumor cell quantity and target regulation of effector functions of tumor stem cells. cancer vaccine Hayleigh Kahn therapeutic cancer vaccine whole cell cancer vaccine