has function has role immunizes against disease immunizes recipient melanoma Homo sapiens melanoma vaccine therapeutic vaccine function vaccine in clinical trial role Melapuldencel-T vaccine Jie Zheng cancer vaccine 5014 https://github.com/vaccineontology/VO/issues/523 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5014 Justin Song A therapeutic melanoma vaccine consisting of autologous dendritic cells (DCs) pulsed with antigens from lethally irradiated autologous tumor cells derived from a patient-specific, continuously proliferating and melanoma-initiating cell line and suspended in a solution containing the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon subcutaneous administration, melapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the patient's repertoire of melanoma-associated antigens, particularly tumor stem cell antigens, found in the irradiated autologous cancer cells. As an immunostimulant, GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes. Yuanyi (Penny) Pan Oliver He therapeutic cancer vaccine