has function has role immunizes against disease immunizes recipient cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role MAGE-A3-expressing Adenovirus Type 5 vaccine cancer vaccine Justin Song https://github.com/vaccineontology/VO/issues/492 Oliver He Jie Zheng Gene name: MAGEA3 An oncolytic adenoviral vaccine composed of a replication-defective, E1- and E3-deleted adenovirus serotype 5 (Ad5) with a transgene encoding the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon administration, MAGE-A3-expressing adenovirus type 5 vaccine selectively replicates in cancer cells and expresses MAGE-A3. This induces an immune response against tumor cells expressing the MAGE-A3 antigen, which leads to tumor cell death. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5336 Yuanyi (Penny) Pan 5336 4102 therapeutic cancer vaccine