has function has role immunizes against disease immunizes recipient fallopian tube cancer ovarian cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role ovarian cancer vaccine light-emitting Oncolytic Vaccinia virus GL-ONC1 vaccine Oliver He Jie Zheng Yuanyi (Penny) Pan cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5385 Gene name: Tumor Associated Antigen An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent and antineoplastic activities. Upon administration, light-emitting oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor vasculature. Once inside the cell, the virus replicates, resulting in tumor cell lysis and the release of mature viral particles into the tumor microenvironment. Released viral particles may then infect and destroy neighboring tumor cells. In addition, the release of tumor-associated antigens (TAAs) by lysed tumor cells into the bloodstream may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against the tumor. The expression of RUC-GFP by this agent allows for both detection and monitoring of virally infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence imaging and fluorescence imaging techniques. https://github.com/vaccineontology/VO/issues/477 Justin Song 5385 therapeutic cancer vaccine