has function has role immunizes against disease immunizes recipient prostate cancer Homo sapiens RNA vaccine therapeutic vaccine function vaccine in clinical trial role RNA vaccine role prostate cancer vaccine mRNA-Derived Prostate Cancer Vaccine CV9103 Justin Song cancer vaccine Oliver He Jie Zheng A prostate cancer vaccine containing mRNAs encoding prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), prostate stem cell antigen (PSCA) and six-transmembrane epithelial antigen of the prostate (STEAP), with potential antitumor activity. Upon administration, mRNA-derived prostate cancer vaccine CV9103 may stimulate the immune system to mount a cytotoxic T lymphocyte response (CTL) against PSA-, PSMA-, PSCA- and STEAP-expressing prostate tumor cells. The mRNA used in this vaccine is modified and formulated to have enhanced translational potency and adjuvant activities. PSA, PSMA, PSCA and STEAP may be upregulated in prostate cancer cells; their expression in prostate cancer has been correlated with disease progression. 26872 Gene name: STEAP1 https://github.com/vaccineontology/VO/issues/542 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5369 5369 Yuanyi (Penny) Pan therapeutic cancer vaccine