has function has role immunizes against disease immunizes recipient cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role virus-like particle vaccine role virus-like particle vaccine HER2 ECD+TM virus-like replicon particles vaccine AVX901 5442 Jie Zheng Oliver He https://github.com/vaccineontology/VO/issues/305 A cancer vaccine based on virus-like replicon particles (VRP) packaged with an alphaviral vector encoding the extracellular domain (ECD) and transmembrane (TM) regions of the human epidermal growth factor receptor 2 (EGFR2, NEU or HER2), with potential antineoplastic activity. After immunization with HER2 ECD+TM virus-like replicon particles vaccine AVX901, the VRPs infect cells and express HER2 ECD+TM protein that may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against HER2-expressing tumor cells. The alphaviral replicon of this vaccine is an attenuated strain of the Venezuelan equine encephalitis virus (VEEV) in which 3 of the 7 viral genes were substituted with a truncated HER2 gene to create a self-amplifying replicon RNA. HER2, a tyrosine kinase involved in several cell growth signaling pathways, is dysregulated or overexpressed in a wide variety of cancer cell types. Yuanyi (Penny) Pan Gene name: ERBB2 2064 Justin Song cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5442 therapeutic cancer vaccine