has function has role vaccinated in route immunizes against disease immunizes recipient cancer Homo sapiens therapeutic vaccine function vaccine in clinical trial role intradermal route therapeutic cancer vaccine whole cell cancer vaccine GM.CD40L cell vaccine Hayleigh Kahn cancer vaccine A cancer vaccine composed of irradiated tumor cells transduced with granulocyte-macrophage colony-stimulating factor (GM-CSF) and CD40-ligand (CD40L) genes. The vaccine may stimulate an anti-tumoral dendritic cell-mediated host immune response. Universal GM-CSF-producing and CD40L-expressing bystander cell line is used to form an autologous tumor cell-based vaccine for patients with mantle cell lymphoma in order to make the body build an effective immune response to kill cancer cells. It can be used in combination with Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, Dexamethasone, and IL-2. The vaccine can be done with bystander and autologous tumor cells for patients with malignant melanoma. It can also be combined with lenalidomide for patients with myelodysplastic syndrome (MDS). NCT: https://clinicaltrials.gov/study/NCT00101101 NCT: https://clinicaltrials.gov/study/NCT00101166 Gene name: CD40LG VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6271 NCT: https://clinicaltrials.gov/study/NCT00840931 959 6271 NCI: https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C48391 Jie Zheng