has function has role vaccinated in route immunizes against disease immunizes recipient leukemia Homo sapiens recombinant vector vaccine subcutaneous route therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role intradermal route leukemia cancer vaccine therapeutic cancer vaccine GVAX leukemia vaccine 6385 PMID:34807983 Jie Zheng cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6385 Hayleigh Kahn 1437 A cancer vaccine that uses irradiated, adenovirus transduced autologous myeloblasts to secrete granulocyte-macrophage colony-stimulating factor (GVAX) early after allogeneic hematopoietic stem cell transplantation (HSCT) to induce potent immune responses. The vaccine may prevent advanced myelodysplastic syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), or acute myeloid leukemia (AML) from relapsing after stem cell transplant. The patients own cancer cells are engineered to produce a protein called GM-CSF, which can be effective in stimulating a powerful immune response specific to that cancer. Gene name: GM-CSF NCT: https://clinicaltrials.gov/study/NCT01773395