has function has role immunizes against disease immunizes recipient cancer Homo sapiens therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role therapeutic cancer vaccine HLA neoantigen vaccine Gene name: HLA VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6377 cancer vaccine Hayleigh Kahn A cancer vaccine for vaccination with neoantigens that can both expand pre-existing neoantigen-specific T-cell populations and induce a broader repertoire of new T-cell specificities in cancer patients, tipping the intra-tumoural balance in favour of enhanced tumour control. The vaccine targets up to 20 predicted personal tumour neoantigens. The vaccine induced CD4+ and CD8+ T cells responses. These T cells discriminated mutated from wild-type antigens, and in some cases directly recognized autologous tumour. 3123 Jie Zheng 6377 PMID:28678778